Table 4. Summary of variants found in germ-line samples from 124 patients with multiple adenomas and 483 random controls
Gene Variants Patients (%) Controls (%) Odds ratio P
APC E1317Q 3/124 (2.4) 6/480 (1.3) 2.0 0.400
CTNNB1 N287S 1/124 (0.8) 3/483 (0.6) 1.32 1.000
AXIN1 P312T, R398H, L445M, D545E, G700S, R891Q 18/124 (14.5) 37/479.3* (7.7) 2.0 0.012
hMLH1 G22A, K618A 5/124 (4.0) 11/482.5* (2.3) 2.0 0.175
hMSH2 H46Q, E808X, ex4SDS 3/124 (2.4) 0/479.3 (0.0) 11.7 0.001
Combined 30/124 (24.9) 55/479.8* , (11.5) 2.2 0.0001
  • SDS, splice donor site variant.

  • * Average number of controls typed for all variants.

  • Two individuals had two variants.