Table 1. UVB-induced hyperplasia in WT, XPA-mock-infected, and XPA-infected mice
Hyperplasia, no. of cell layers*
Time after UV treatment XPA mock XPA + AdyXPA WT
24 h 0.1 ± 0.2 [I] 0.2 ± 0.21 5.2 ± 1.1
[BI] 8.3 ± 0.7
3 weeks 20.2 ± 3.4 [I] 12.1 ± 1.9 2.9 ± 0.5
[BI] 3.9 ± 1.4
2 months 22.3 ± 2.3 [I] 5.3 ± 1.1 2.1 ± 2.8
[BI] 2.5 ± 1.5
  • * Hyperplasia is given as the number of epidermal cell layers at the indicated times after in vivo exposure to UVB. Data are means ± SEM (n ≥ 3) or variation (n = 2).