Table 4. ETC genes and lineages with significant GO annotations and additional ETC genes and lineages that change unambiguously
Complex Gene Human Chimpanzee Human–chimpanzee Gorilla African ape–macaque*
I GRIM19 U (21–22) U (11–21)
NDUFA2 D (22–18)
NDUFA4 U (22–24)
NDUFA10 U (21–22) U (10–21)
NDUFA11 U (11–22)
NDUFAB1 U (19–23)
NDUFB1 U (21–22)
NDUFB4 U (22–23)
NDUFB8 U (3–8) U (12–23)
NDUFC2 U (22–23)
NDUFS4 U (17–18) U (15–17)
NDUFS6 U (15–17)
III HSPC051 U (14–23)
UQCRC2 U (18–20) D (18–14)
UQCRH U (21–23)
IV COX4I1 U (20–23)
COX5A U (20–22)
COX5B U (22–23) U (11–23)
COX7C U (23–24)
V ATP5C1 U (22–23) U (21–22)
ATP5G3 D (22–20)
ATP5H U (23–24)
ATP5J2 U (20–22)
ATP1F1 N D (19–11)
Other CYCS U (23–24)
Total genes 25 10 6 3 3 11
  • See Results and Tables 6–10 for a full listing of these ETC-related GO annotations. Bold, ETC genes that change unambiguously on one or more relevant branches. U, up-regulated; D, down-regulated. Numbers in parentheses indicate the bin categories spanned by each change.

  • * Change on the ancestral African ape node with respect to the ancestral macaque node; N, indeterminate, because different probe sets for the same gene showed opposite directions of change