Table 1. HuR motif-bearing targets on cDNA arrays
Motif position and score Accession no. Gene
969 (3.42) Hs#S3322070 Matrix metalloprotease 7 (MMP7)
1714 (1.42), 1783 (0.78) Hs#S1726209 Actin, gamma 1 (ACTG1)
537 (1.00), 750 (0.42) NM_004181.3 Ubiquitin thiolesterase (UCHL1)
1434 (2.00), 1492 (2.42), 1515 (1.42) Hs#S5494967 Sorting nexin 3 (SNX3), transcript variant 3
571 (0.42), 929 (0.29), 977 (0.42) Hs#S1727443 Protein phosphatase 1, catalytic subunit β (PPP1CB)
1417 (0.36), 1610 (1.83), 2332 (2.42)
2414 (0.83), 2707 (0.42), 3423 (4.00)
3439 (4.00), 3515 (0.01)
2824 (0.42) Hs#S1729935 Solute carrier family 1 (SLC1A5)
3848 (1.71), 1184 (0.42) Hs#S1728144 Ubiquitin-conjugating enzyme E2N (UBE2N)
436 (0.42), 2470 (2.38) Hs#S1729115 Metastasis-associated 1 (MTA1)
3845 (0.29) Hs#S1824446 Leucine zipper-EF-hand transmembrane (LETM1)
2320 (1.42) Hs#S1730282 Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2)
496 (1.36), 626 (0.42), 734 (0.01) Hs#S1727788 Chemokine (C-X-C motif) ligand 6 (CXCL6)
789 (0.29), 1311 (0.42)
1263 (0.29), 2039 (3.42), 3111 (1.42) Hs#S1731058 Poliovirus receptor (PVR)
2876 (0.83), 3288 (0.42), 3533 (0.01), 3564 (0.42), 3727 (0.42), 3958 (1.42), 4032 (1.42), 4078 (0.42), 4310 (2.00), 4340 (0.29), 4497 (1.88), 4566 (0.42) Hs#S2294124 Minichromosome maintenance deficient 10 (MCM10)
791 (1.42) Hs#S1731210 Ribosomal protein L14 (RPL14)
768 (2.65), 797 (0.88), 1031 (0.83), 1103 (0.42) Hs#S1727552 Prothymosin, alpha (PTMA)
1102 (1.42), 1210 (0.29), 1235 (0.01) Hs#S3438634 RNA processing factor 1 (RPF1)
1934 (1.29), 3085 (0.42), 3323 (0.01), 3359 (2.42), 3622 (1.42) Hs#S1731856 Karyopherin alpha 4 (importin alpha 3) (KPNA4)
724 (0.42), 2028 (0.83) Hs#S4631077 Crystallin, zeta (quinone reductase)-like 1 (CRYZL1)
580 (4.00), 828 (0.42), 985 (1.42) Hs#S1731044 RNA polymerase II transcription cofactor 4 (PC4)
691 (3.29), 1519 (0.29) NM_000801.2 FK506 binding protein 1A, 12 kDa (FKBP1A)
  • Partial list of genes encoding transcripts more abundantly found in HuR immunoprecipitates; these were used to create the experimental data set and derive the HuR motif. The relative position(s) of the HuR motif within each transcript and the corresponding scores (parentheses, bold) are indicated. A complete list of transcripts enriched in HuR IP compared with IgG1 IP is available as supporting information on the PNAS web site.