Table 2.

Comparisons of computationally reconstructed ancestral chromosomes with reconstructions made using Zoo-FISH or BAC-FISH

AncestorInterchromosomal event*DESCHRAMBLERANGESinferCARsMGRA
Eutherian4q-8p-4pq
3–21+++
14–15+
10p-12pq-22q
16q-19q+++
16p-7a++
12q-22q++++
Boreoeutherian4–8p++++
3–21+++
14–15+++
10p-12pq-22q
16q-19q++
16p-7a++
12q-22q++++
Simian3–21+++
14–15+++
Consistent1211104
Inconsistent45612
  • Chromosome fusions are indicated with a hyphen between chromosomes. A plus sign denotes that the fusion of chromosomes was detected in the ancestral genome. A minus sign denotes that the fusion of chromosomes was not detected in the ancestral genome. Sources of FISH data used for the comparisons: eutherian (8), boreoeutherian (6), and simian (20) reconstructed ancestral chromosome. “+” indicates that the adjacency detected by FISH was also detected by the algorithm. “−” indicates that the adjacency detected by FISH was not detected by the algorithm.

  • * Numbers represent human chromosome numbers, and “p” and “q” indicate the p-arm and q-arm, respectively. If a chromosome fragment does not perfectly match to the p- or q-arm, a letter is used based the order of the fragment on the chromosome.