Table 4. Mutations in previously uncharacterized genes that affect early morphogenesis
Mutant Phenotype Map position Chr:cM Gene
Gastrulation arrest
F8 Arrest at e8.0, small embryonic region 7: 53-57.5
W3 Arrest at e8.0, small embryonic region 11: 49-54
dimple (dmpl) Arrest at e8.0, abnormal primitive streak 6: 37-43
S2 Arrest at e8.0, dead cells in amniotic cavity 15: 39-44
T6 Arrest at e8.0, small embryonic region 5: 18-19
M1ec Arrest at e7.0 3: 39-41
lazy mesoderm (lzme) Arrest at e8.0; streak bulges into amniotic cavity 5: 38 Ugdh (12)
Early somite stage arrest wing-shaped neural plate (wsnp) Deficit in paraxial and axial mesoderm, arrest at e8.5 16: 27-28
limulus (lulu) Deficit in paraxial and axial mesoderm; arrest at e8.5 1: 63 Epb4.115 *
chato Arrest at e8.5 outside of yolk sac 7: 10-16
mermaid Deficit in paraxial mesoderm; arrest at e8.5 8: 59-72
kahloista (khlo) Arrest unturned, small somites 2: 45-47.8 Nap1
99J1 Arrest unturned 5: 64-80
15A Deficit in paraxial mesoderm 17: 30-42
1A Arrest unturned, abnormal heart 11: 52-70
nero Arrested unturned, no left-right asymmetry; arrest at e9.5 3: 25-35 dolichyl-phosphate β-glucosyltransferase
M2 Attest at e9.0, unturned 4: 56.5
e9.5 arrest
19C Abnormal heart, arrest at e9.5 16: 28-57
38D/p Swollen lateral plate, abnormal somites 2: 41-48
8A Small, twisty tail 13: 30-43
Left-right abnormal
3B Randomized polarity of heart looping, survives past midembryogenesis 7: 10-46.5
  • * J.D.L. and K.V.A., unpublished results.

  • A.S.R. and K.V.A., unpublished results.

  • E.H.F., A.S.R. and K.V.A., unpublished results.