Table 1. Effect of griseofulvin on the dynamics of individual microtubules
Griseofulvin concentration, μM
Parameter 0 0.5 1 5 20
Rate, μm/min
    Growing 1 ± 0.10 0.73 ± 0.11 0.84 ± 0.20 0.5 ± 0.07 0.44 ± 0.01
    Shortening 19.9 ± 0.22 15.6 ± 1.3 12.4 ± 0.22 6 ± 0.24 5.1 ± 0.24
Length change, μm
    Growing 1.2 ± 1.1 1.4 ± 1.3 1.64 ± 1.6 1.4 ± 1.3 1.4 ± 1.3
    Shortening 4.5 ± 4.3 4.9 ± 1.1 4.1 ± 3.9 2.4 ± 2.2 1.8 ± 1.6
Percent time in phase
    Growing 78.8 59.7 64.4 39.4 48.5
    Shortening 15.1 7.7 5.8 7.4 4.1
    Attenuation 6.1 32.6 29.8 53.2 47.4
Frequency, no./min
    Catastrophe 0.49 ± 0.10 0.2 ± 0.04 0.08 ± 0.02 0.05 ± 0.01 0.05 ± 0.01
    Rescue 1.9 ± 0.48 1.3 ± 0.42 1.1 ± 0.27 0.68 ± 0.20 1.1 ± 0.36
Dynamicity, μm/min 2.6 1.2 0.85 0.35 0.28
  • Data are given as mean ± SEM.