Table 1. Metabolite levels and ATP turnover in normal subjects and patients with heart failure
Tissue PCr, μmol/g wet wt ATP, μmol/g wet wt kfor, sec−1 CK flux, μmol/g wet wt per sec n
Chest wall
Normal 27 ± 8* 8.2 ± 2.4 0.22 ± 0.07 5.7 ± 2.2 14
Heart failure 26 ± 8 8.4 ± 3.4§ 0.21 ± 0.08§ 5.1 ± 2.2§¶ 13
Cardiac muscle Normal
Rest 10.1 ± 1.3 5.7 ± 1.3 0.32 ± 0.07 3.2 ± 0.9 16
Dobutamine 9.9 ± 1.2 5.6 ± 1.4 0.33 ± 0.09 3.3 ± 1.2 6
Heart failure 8.3 ± 2.6** 5.2 ± 1.3 0.21 ± 0.07†† 1.6 ± 0.6†† 17
  • Data are mean ± SD. *, P < 0.0001 vs. heart in same subjects; †, P < 0.003 vs. heart in same subject; ‡, chest muscle was not unambiguously identified in two normal subjects; §, P = not significant vs. chest in normal subjects; ¶, P < 0.002 vs. heart in same subjects; ∥, chest muscle was not unambiguously identified in four heart failure patients; **, P = 0.03 vs. normal; ††, P < 0.0005 vs. normal.