Table 1. Caerulein responses in acinar cells
Zymogen activation: chymotrypin, %
Enzyme secretion: amylase, %
Treatment + +
Dantrolene (75 μM)
Control 14.4 ± 6.4 11.4 ± 4.9 3.4 ± 0.9 2.9 ± 0.6
Caer (100 nM) 71.5 ± 6.3 49.1 ± 4.3 10.4 ± 2.6 9.6 ± 2.5
Caer + VIP 100 74.0 ± 4.9 11.4 ± 2.1 11.4 ± 2.6
Caer + 8-b-cAMP 265.1 ± 20.6 79.2 ± 2.2 15.1 ± 1.5 15.0 ± 2.5
Ryanodine (100 μM)
Control 2.6 ± 2.4 3.0 ± 3.0 2.1 ± 0.7 2.9 ± 1.8
Caer (100 nM) 100 62.2 ± 6.4 9.6 ± 0.5 9.5 ± 0.4
Caffeine (10 mM)
Control 2.1 ± 0.7 4.0 ± 1.3 4.5 ± 0.9 5.3 ± 0.4
Caer (100 nM) 100 36.4 ± 12.1 12.5 ± 2.1 12.3 ± 2.2
  • Values are ±SD. Caer, caerulein; 8-b-cAMP, 8-bromo-cAMP. *, P < 0.01.