Table 1. Inhibitory activity of cymserine and analogs against human and rat erythrocyte AChE and plasma BChE
Human IC50, nM
BChE selectivity
Rat IC50, nM
BChE selectivity
Compound AChE BChE AChE BChE
Cymserine 760 ± 20 50 ± 1 15-fold 800 ± 25 38 ± 7 21-fold
PEC >30,000 6 ± 1 >5,000-fold >30,000 9 ± 2 >3,300-fold
BNC 110 ± 15 1 ± 0.1 110-fold 150 ± 20 1 ± 0.5 150-fold