Table 3. Univariate analysis of overall survival
Variable Hazard ratio 95% C.I. P
Age, years (continuous) 1.03 1.01–1.05 0.01
Stage I/II vs. III/IV 2.72 0.85–8.72 0.09
Grade 1/2 vs. 3 1.26 0.50–3.14 0.63
Histology, serous vs. others 0.66 0.32–1.34 0.25
Residual tumor, absent vs. present 1.20 0.71–2.05 0.50
Stromal TILs (lowest tertile vs. all others)
   CD3+ 0.70 0.40–1.20 0.19
   CD4+ 0.89 0.51–1.56 0.68
   CD8+ 0.71 0.41–1.22 0.22
   CD8+/CD4+ ratio 1.23 0.70–2.16 0.48
   CD20+ 0.77 0.45–1.32 0.34
Intraepithelial TILs (lowest tertile vs. all others)
   CD3+ 0.92 0.54–1.55 0.74
   CD3+ (according to Zhang et al. in ref. 6) 0.89 0.53–1.49 0.64
   CD4+ 0.84 0.50–1.40 0.50
   CD8+ 0.51 0.30–0.85 0.01
   CD8+/CD4+ ratio 0.42 0.25–0.72 0.002
   Treg 1.28 0.74–2.24 0.38
   CD25+FOXP3 0.61 0.35–1.04 0.07
   CD8+/Treg ratio 0.33 0.18–0.59 0.0002
   CD8+/CD25+FOXP3 ratio 0.98 0.56–1.71 0.94
  • Univariate Cox proportional hazards model. Whereas high intraepithelial CD8+ TILs, CD8+/CD4+ ratio, and CD8+/Treg ratio were associated with improved survival, stromal TIL subtypes and other intraepithelial TILs were not significant. Age, stage, grade, histological type, and presence of residual disease were adopted as covariates. Classification of CD3+ TILs by Zhang et al. (6) was applied but was not associated with improved survival.