Table 1. Weight gain, water intake, serum zonulin levels, and presence of ICA in BBDP rats either untreated and with development of T1D (control) or treated with FZI/0 and with no development of T1D
Age, days
Weight gain, g/week
Water intake, ml/day
FZI/0 intake, μg/100 g of body weight
Serum zonulin, ng/mg protein
Serum ICA, % ICA-positive rats
Control FZI/0 Control FZI/0 Control FZI/0 Control FZI/0
30 11.4 ± 3.96 12.3 ± 2.94 28.2 ± 13.1 27.5 ± 9.9 22.0 0.2 ± 0.1 0.2 ± 0.2 0 0
37 17.5 ± 3.09 17.4 ± 2.86 42.6 ± 12.3 39.9 ± 11.8 31.9 0.7 ± 0.2 0.9 ± 0.4 9 0
44 23.9 ± 3.10 23.3 ± 3.44 46.3 ± 16.5 44.5 ± 14.4 35.6 2.2 ± 0.5 2.5 ± 0.7 50 0
51 29.6 ± 2.78 29.5 ± 3.12 50.5 ± 15.4 41.5 ± 11.7 33.2 4.8 ± 0.6 5.3 ± 0.9 83 9
58 31.5 ± 1.96 30.6 ± 3.61 47.0 ± 13.8 47.2 ± 14.2 37.8 4.7 ± 1.1 4.4 ± 1.3 92 9
65 35.8 ± 1.76 35.9 ± 2.80 56.9 ± 25.0 52.4 ± 20.4 41.9 4.9 ± 0.9 5.2 ± 1.6 92 9
72 37.5 ± 3.11 37.0 ± 4.37 59.4 ± 25.6 47.7 ± 17.9 38.2 4.7 ± 1.9 5.0 ± 1.5 92 9