Table 2.

HI serology and survival of chickens before and after challenge

Vaccine group*HI serology before challenge (GMT)
Challenge virusNo. of survivorsHI serology 14 days after challenge (GMT)
AIV/H7 antigenNDV antigenAIV/H7 antigenNDV antigen
rNDV/F3aa-chimericH7, 1×8/10 (11)10/10 (49)vNDV10/109/10 (15)10/10 (416)
rNDV/F3aa-chimericH7, 1×7/10 (10)10/10 (49)HPAIV9/109/9 (2,048)9/9 (37)
rNDV/F3aa-chimericH7, 2×8/10 (13)9/10 (56)vNDV10/107/10 (17)10/10 (315)
rNDV/F3aa-chimericH7, 2×5/10 (9)9/10 (60)HPAIV9/108/8 (955)8/8 (30)
pNDV, 2×0/1010/10 (34)vNDV10/100/1010/10 (294)
pNDV, 2×0/1010/10 (56)HPAIV0/10NANA
Sham, 2×0/100/10vNDV0/10NANA
Sham, 2×0/100/10HPAIV3/100/30/3
  • Chickens were vaccinated with rNDV containing the AIV H7 HA gene (rNDV/F3aa-chimericH7), pNDV, or sterile tissue culture fluid (sham), followed by challenge with vNDV and A/Human/Steele/59 (H7N7) HPAI virus (HPAIV). HI serology is shown as no. of chickens with HI-positive serum/no. of chickens vaccinated; values in parentheses are geometric mean titer (GMT). NA, not applicable.

  • *n = 10 birds per group; 1× = one vaccination; 2× = two vaccinations.