Table 2.

Selected functional categories of mutated genes in the 96-month isolate from patient 1

Functional categoryNo. of genes mutated
Virulence factors, virulence regulators13
Small-molecule transport, antibiotic resistance12
Iron acquisition5
DNA replication, cell division, transcription, translation5
Quorum sensing3
Fatty-acid metabolism3
DNA mismatch repair1
Anaerobic metabolism1