Table 3.

Passive protection in the infant rat meningococcal bacteremia model

Exp.2996 (challenged CFU)TreatmentSerum dilution or dose of mAb, μg, per ratNo. positive/totalCFU/ml (geometric mean)
163,000Anti-PorA(Pl.2) mAb20/3<1
Anti-B5CVMB mouse serum1:50/3<1
1:200/3<1
Anti-5CVMB rabbit serum1:50/3<1
1:200/35
PBS control3/3146,590
25,000Anti-PorA(Pl.2) mAb10/4<1
Anti-5CVMB mouse serum1:100/4<1
1:500/4<1
Anti-5CVMB rabbit serum1:100/4<1
1:500/4<1
PBS control4/48,250
  • CFU, colony-forming unit.