Table 1.

Growth inhibition (IC50) across various cell lines by MLN8054

Cell lineOriginMLN8054, μM
HCT-116Colon tumor0.18 ± 0.06 (3)
SW480Colon tumor0.86 ± 0.40 (2)
DLD-1Colon tumor1.43 (1)
MCF-7Breast tumor0.67 (1)
MDA-MB-231Breast tumor0.74 ± 0.01 (2)
Calu-6Lung tumor0.22 ± 0.09 (3)
H460Lung tumor0.11 ± 0.06 (2)
SKOV-3Ovary tumor0.53 (1)
PC-3Prostate tumor0.79 (1)
  • Numbers represent average IC50 ± SD derived from a BrdU cell proliferation ELISA. Values in parentheses represent the number of experiments completed for each cell line.