Table S4.

G4-escape data

Amino acid changeDomainOccurrence*Frequency (% of isolates)
R1179TCD17.7
T1175PCD17.7
R1179MCD17.7
V1150ACD17.7
A886PS2′17.7
R1179GCD215.4
S1185LCD215.4
T1175ICD538.5
  • * Occurrence is the number of times a given substitution was found in any of the 13 independent G4-resistant isolates. One isolate contained two of the listed substitutions, and thus the total number of occurrences is 14.

  • Connector domain.

  • S2′ protease site.