Table 1.

Functions of proteins deleted in strains identified by Kir* screen

NameORFLocalizationFunctionDeletion phenotype
SUR4 YLR372WERElongase for very long-chain fatty acidsReduced VLCFA levels; lipid raft association and targeting of H+ ATPase disrupted (17, 30, 39, 41)
CSG2 YBR036CERRegulatory subunit of mannosyl-tranferases Csg1p and Csh1pReduced mannosylinositol phosphorylceramide levels (18, 40)
ERV14 YGL054CERCOPII vesicle packaging chaperoneER retention of TM proteins Axl2p and Sma2p; delay in ER exit of GPI-anchored proteins (19, 20)
EMP24 YGL200CCOPII vesiclesCargo receptor in p24 protein familyDelay in ER exit of GPI-anchored proteins and soluble cargo; secretion of ER proteins; suppression of sec13Δ (21, 24, 34–36)
ERV25 YML012WCOPII vesiclesCargo receptor in p24 protein family
BST1 YFL025CERGPI inositol deacylaseDelay in ER exit of GPI-AP; secretion of ER proteins; suppression of sec13Δ (22, 23, 36, 48)
TED1 YIL039WERUncharacterizedUncharacterized