Table 4.

Predictive values of each marker to identify three clusters

Markerκ coefficientSpecificity, %Sensitivity, %PPV, %NPV, %
CIMP1
Genetic
    BRAF-MT0.6099539188
    MSI-H0.8296868696
Epigenetic
    hMLH1-M0.911008610096
    TIMP3-M0.6284866195
    MINT17-M0.5284735791
    MINT1-M0.4975865095
    RIZ1-M0.4893506986
    SOCS1-M0.4786635590
    MINT12-M0.4476774992
    RUNX3-M0.4385605289
    P16-M0.4181645088
    MINT31-M0.3871774491
    P14-M0.3683554886
CIMP2
Genetic
KRAS-MT0.858810084100
    P53-WT0.3060725377
    MSS/MSI-L0.313710049100
Epigenetic
    MINT27-M0.3963785783
    MINT2-M0.3068625575
    Neurog1-M0.3071595673
    MINT31-M0.2268545171
    Megalin-M0.2172495169
    MINT1-M0.1567494768
    hMLH1-UM0.263210047100
CIMP-negative
Genetic
    P53-MT0.7081927594
    KRAS-WT0.4163815984
Epigenetic
    MINT27-UM0.7181927694
    MINT2-UM0.5868956595
    MINT31-UM0.5363956295
    MINT1-UM0.5563976397
    MINT12-UM0.4656955894
    Neurog1-UM0.4560895990
    P16-UM0.414710055100
  • PPV, positive predictive value; NPV: negative predictive value; MT, mutation; M, methylated; UM, unmethylated.