Table 5.

Predictive values for combination markers to identify each of the three clusters

Positive, no.κ coefficientSpecificity, %Sensitivity, %PPV, %NPV, %
CIMP 1 (BRAF-Mutation, hMLH1-Meth, Timp3-Meth, MINT1-Meth, and RIZ1-Meth)
2 of 50.8095868396
3 of 50.8199779494
CIMP2 (KRAS-Mutation, MINT27-Meth, MINT2-Meth, MINT31-Meth, and Megalin-Meth)
2 of 50.4060845686
3 of 50.3045895087
CIMP Negative (p53-Mutation, MINT27-Unmeth, MINT2-Unmeth, MINT31-Unmeth, MINT1-Unmeth)
2 of 50.556110062100
3 of 50.727610073100