Table 1.

IC50 and IC90 values for SGX393 in cellular proliferation assays

Cell LinesSGX393
IC50, nMFold IC50IC90, nM
Ba/F3 cells
    Native Bcr-Abl121.084
    M244V211.847
    G250E619543,609
    Q252H24121894
    Y253F696603,548
    Y253H17615440
    E255K20718585
    E255V2,2101914,795
    F311L25022465
    T315A121.039
    T315I7.30.628
    F317L598523,242
    M351T151.3117
    F359V100.947
    V379I131.156
    L387M121.057
    H396P5.60.515
    H396R181.549
    Parental3,632314>5,000
CML leukemia cells
    K56213NA24
    BV17316NA70
Non-CML leukemia cells
    CMK3,129NA>5,000
    CTV2,088NA4,742
    HL603,621NA>5,000
    Marimo3,986NA>5,000