Table 1.

Summary of phospho-tyrosine profiling of 7 NSCLC cell lines

Cell lineMutation status of EGFR, KRASGefitinib sensitivity (IC50, μM)Phospho-peptidesNonredundant phospho-proteinsNonredundant phospho-peptidesNonredundant phospho-sites
H358KRAS: G12V≈10222728984
H1650EGFR: E746-A750del>10321180251220
H1666EGFR: wt; KRAS: wt≈4374219303278
H1734KRAS: G13C>10317201270249
H1975EGFR: L858R, T790M>10371202302275
HCC827EGFR: E746_A750del<0.1762369575508
H3255EGFR: L858R<0.1754373547509