Table 1.

Comparison of amino acid contacts at the LIR-1/UL18 and LIR-1/HLA-A2 interfaces

LIR-1UL18HLA-A2
D1UL18HLA-A2
    Arg-36    Asp-202*    Asp-196*
    Leu-37    Asn-201    None
    Tyr-38    Asn-201, Arg-204, Asp-233    Val-194, Ser-195
    Arg-39    None    Val-194
    Glu-40    Asp-233    None
    Lys-41    Asp-233, Glu-235*, Gln-237, Tyr-254, Ala-256    Val-194, Glu-198, Val-248
    Lys-42    Tyr-254    None
    Thr-43    Asn-199, Glu-206    Ala-193
    Thr-48    Gln-200, Asn-201    None
    Tyr-76    Asp-202, Asn-203    Asp-196
    Arg-84    Asp-202, Asn-203    None
D1β2m in LIR-1/UL18β2m in LIR-1/HLA-A2
    Gln-18    Gln-89    Gln-89
    Lys-42    None    Asp-96*
    Trp-67    None    Lys-91, Ile-92, Val-93
    Glu-68    None    Lys-94
    Gly-97    Ser-88    Ser-88
    Ala-98    Leu-87, Ser-88    Leu-87, Ser-88
D2β2m in LIR-1/UL18β2m in LIR-1/HLA-A2
    Tyr-99    Thr-4, Thr-86, Lys-91    Thr-4, Thr-86, Lys-91
    Ile-100    Gln-2, Val-85, Thr-86    Val-85, Thr-86
    Ser-124    Ile-1    None
    Gln-125    Ile-1, Gln-2    Ile-1, Gln-2
    Val-126    Ile-1, Gln-2, Thr-4, Thr-86    Gln-2, Arg-3, Thr-4, Thr-86
    Ala-127    Ile-1, Gln-2, Arg-3    Gln-2, Arg-3
    Ser-155    Ile-1    None
    Glu-184    Lys-91    Lys-91
    Leu-187    Ser-88    Ser-88
  • *Salt bridge.

  • Hydrogen bond.