Table 4.

Mutations (rpoB) fully explain growth advantage

MutationSelected rpoB mutant
Constructed rpoB mutant
Median CI(Dev)NMedian CI(Dev.)N
Q513H12.9(5.9)155.5(10)16
R529S40.6(45)1273.9(100)11
P564L27.8(93.2)1142.3(18.4)16
  • *P values (CI of mutant significantly different from CI of wild type by Mann–Whitney nonparametric test) were <0.0001 for all competitions.

  • Dev. is the absolute average deviation from the median (see Materials and Methods). Note: the CI was positive for all competitions.

  • N is the number of independent colony competitions for each mutant.