Table 2.

Two-locus haplotype transmissions of HLA-DRB1*15HLA-B and HLA-DRB1*XHLA-B from HLA-DRB1*15 positive (n = 536) and negative parents (n = 452)

HLA-DRB1*15 Positive Parents (n = 536)
HLA-DRB1*15 Negative Parents (n = 452)
Comparison
HaplotypesTRNTORχ2PHaplotypesTRNTORχ2Pχ2P
15-72631042.5371.223.19 × 10−17X-760581.030.030.8517.393.044 × 10−5
15-825231.090.080.77X-868611.110.380.540.00560.94
15-134100.402.660.10X-1311160.690.930.340.590.44
15-14641.500.400.53X-1414121.170.150.690.28
15-15623.002.090.15X-1529261.120.160.690.16
15-183174.4316.375.20 × 10−5X-1831211.481.920.170.016
15-2718171.060.030.87X-2733231.431.790.180.490.48
15-3519111.732.160.14X-3567820.821.510.223.370.066
15-371243.004.190.041X-3711150.730.620.430.031
15-38260.332.090.15X-383100.303.770.0520.39
15-39300.004.160.041X-399240.386.820.00900.031
15-402163.508.830.0030X-4014170.820.290.590.0090
15-41240.500.680.41X-41541.250.110.740.29
15-4447241.967.590.0059X-4471661.080.180.673.940.047
15-492092.224.280.039X-496170.355.260.0220.0020
15-512245.5013.720.00021X-5126261.000.001.000.0022
15-52160.173.960.047X-52111.000.001.000.39
15-55300.004.160.041X-55280.253.600.0580.035
15-56140.251.930.17X-56200.002.000.160.14
15-572036.6714.070.00018X-5719151.270.470.490.011
15-58641.500.400.53X-58370.431.600.210.15
15-60140.251.930.17X-6016180.890.120.730.22
15-62300.004.160.041X-6227241.130.180.670.16
15-64240.500.680.41X-6414220.641.780.180.34
TOTAL5382602.06996.857.49 × 10−23TOTAL5425730.950.860.3555.469.54 × 10−14
  • HLA-DRB1*X refers to any allele other than HLA-DRB1*15.

  • Fisher's exact test was used when the expected transmissions in any of the cells of the table were below 10. Uninformative MS families were excluded in this analysis, which may contain parents homozygous for both class I/II, and/or HLA identical parents for both class I/II, and/or with missing class I/II typing.