Table 2.

Coadministration of VPA and Clozapine (CLZ) fail to alter the levels of SAM (S-adenosyl methionine) and SAH (S-adenosyl homocysteine) in FC of mice receiving MET

Pretreatment(7 days)Posttreatment(3 days)SAM, pmol per mg of proteinSAH, pmol per mg of protein
Vehicle*Vehicle309 ± 2145 ± 2.0
MET550§ ± 5069§ ± 7.0
METVehicle375 ± 3548 ± 3.5
METVPA + CLZ387 ± 2750 ± 4.0
  • Each value is the mean ± SE of three mice.

  • *Vehicle, twice a day s.c. for 7 days.

  • Vehicle (twice a day s.c. for three days following MET treatment termination.

  • MET, 5.2 mmol/kg s.c. twice a day.

  • §P < 0.05 when compared with vehicle treated mice.

  • VPA (0.5 mmol/kg s.c.) + CLZ (15 μ mol/ kg s.c.) twice a day for three days following MET treatment termination.