Table 1.

Ratio of effector CD4+ICOShi to regulatory CD4+FOXP3+ T cells in the peripheral blood of patients before and after treatment with anti-CTLA-4 antibody

CD4+CD4+ICOShiCD4+FOXP3+Ratio of CD4+ICOShi/CD4+FOXP3+
Patient #1
    Pre-therapy210,4136,3128,4170.8
    Week 3190,97626,73617,1881.6
    Week 7191,46724,89111,4882.2
Patient #2
    Pre-therapy139,48355843,3240.0
    Week 3176,35931,74515,6882.0
Patient #3
    Pre-therapy135,5494,06623,7060.2
    Week 3130,56019,58453,1120.4
    Week 7156,79226,65512,9392.1
Patient #4
    Pre-therapy143,9755,75910,0780.6
    Week 3134,25910,7414,0282.7
    Week 7164,54313,1634,9362.7
Patient #5
    Pre-therapy209,4414,18958,6440.1
    Week 3272,62154,524119,9530.5
    Week 7238,43442,91821,4592.0
Patient #6
    Pre-therapy15,63811,56412,5110.1
    Week 316,23899,74311,3670.9
    Week 715,941114,3476,3762.3
  • Values are numbers of cells per million collected events by flow cytometry.