Table 4.

In vivo activity of PA1103/SAR116242 against the erythrocytic forms of P. falciparum in humanized mice

CompoundDose, mg/kg per dayP. falciparum strainParasitemia reduction at D4, %
Chloroquine153D7100 (n = 3)
15W20 (n = 5)
433D7100 (n = 5)
43W215 (n = 5)
Artesunate43D728 (n = 3)
4W289 (n = 4)
543D7ND
54W2100 (n = 4)
PA1103/SAR116242323D7ND
32W277 (n = 4)
633D7100 (n = 4)
63W296 (n = 5)
  • 3D7: in vitro CQS strain; W2: in vitro CQR strain. n = number of mice per group. ND = nondetermined value.