Table 2.

Cellular GI50 determinations for PLX4720 versus a panel of cell lines

Cell lineB-Raf sequencePLX4720 proliferation GI50, μMPLX4720 P-ERK GI50, μMPD0325901 P-ERK GI50, μM
COLO205V600E0.310.014<0.002
A375V600E0.500.046<0.002
WM2664V600D1.5
COLO829V600E1.70.044<0.002
HT716Wild type10
SW620Wild type13>40<0.002
H460Wild type24
Calu-6Wild type26
HCT116Wild type27
SK-MEL2Wild type2723<0.002
SK-MEL3Wild type27
LovoWild type29
H1299Wild type41