Table 1.

IGF1R variants in centenarians and controls

CategoryNucleotide changeProtein changeCentenarians, n = 79
Control, n = 161
HetHomHetHom
Nonsynonymous 244G>A Ala-37–Thr 1000
1355G>AArg-407–His1000
Synonymous948C>AGly-271–Gly70160
1545G>A Thr-470–Thr 1000
1959C>TAsn-608–Asn0010
1995G>T Arg-620–Arg 0010
2343C>TThr-736–Thr3020
2745C>T Asn-870–Asn 1030
3174G>AGlu-013–Glu48206729
4083C>TTyr-1316–Tyr5070
4103C>T Arg-1323–Arg 1000
IntronicIVS2+20C>T4286512
IVS8–20T>C49136734
IVS13+17G>A 1020
IVS13+21A>C4736241
IVS13+29_30delGT261383
IVS15+49insG 1000
IVS15+52A>G 0010
IVS17−5C>T 1030
IVS21–34G>A46155942
  • Het, number of heterozygote carriers of variant; Hom, number of homozygote carriers of variant. Previously unknown, novel variants are indicated in bold.