Table 1.

Predicted RXR/PPAR binding elements in BACE1 promoter region

FamilyMatrixPositionStrandSequence
V$RXRFV$PXR_RXR.01−1357/−1333+caggtgGGTCatgaggattcatatc
V$PEROV$PPAR_RXR.01−1239/−1217+tccctgttggatacTGGTgagtg
V$RXRFV$CAR_RXR.01−1070/−1046gttcaaGGACagccaagactacata
V$RXRFV$CAR_RXR.01−398/−374tgctcaGGCCaccataatccagctc
  • The putative PPAR/RXR heterodimer binding sites in the rat BACE1 promoter predicted by the online program MatInspector (www.genomatix.de). V$ represents the vertebrate family. The capital letters in the sequence represent core sequence, and the underlined regions represent ci-value > 60, according to matrix family assignment with the RXR consensus sequences. The adenine+1 represents the translational start site.