Table 1.

Antibody affinities for EGFR epitopes

EGFR fragment couplingKD for mAb175, nMKD for mAb806, nM
287–302 (Pms-Ser)35 ± 616 ± 8
287–302 (Thiol)143 ± 284 ± 3
287–302 (Amine)154 ± 0.185 ± 0.3
1–501* (Amine)16 ± 0.0334 ± 0.03
1–621 (Amine)188 ± 0.01389 ± 0.01
  • *Unable to form tether.

  • Can form tether.