Table 1.

Hazard ratios (HRs) and 95% Confidence Intervals (CIs) for TNM stage, MI, CD3 count, and TIL based on 3 multivariable Cox proportional hazards models of postrecurrence survival

AHR (95% CI)p value
    TNM stage* IIIA/IIIB vs. IIIC/IV2.05 (0.76, 5.54)0.16
    Mitotic Index2.13 (1.38, 3.32)0.0008
B
    TNM stage* IIIA/IIIB vs. IIIC/IV1.82 (0.70, 4.74)0.22
    TILs0.26 (0.10, 0.69)0.0067
C
    TNM stage* IIIA/IIIB vs. IIIC/IV1.27 (0.46, 3.56)0.64
    CD3 count0.80 (0.70, 0.92)0.0022
  • All three histologic parameters, MI, CD3, and TILs, add to the ability of TNM stage in predicting postrecurrence survival. A, HRs and 95% CIs for TNM stage and MI based on a Cox regression model involving these variables. B, HRs and 95% CIs for TNM stage and TIL based on a Cox regression model involving these variables. C, HRs and 95% CIs for TNM stage and CD3 count based on a Cox regression model involving these variables.

  • *Due to small sample size, TNM stage was dichotomized (IIIA/B vs. IIIC/IV). The other three variables were dichotomized for convenience using medians as cut-off points.