Table 4.

Replication results for OBFC1 and CXCR4

OBFC1 genotype*123P
Whites of European descent (n = 1,319)
 rs4387287 (C/A)6.80 ± 0.0246.88 ± 0.0387.03 ± 0.0830.013
 rs9419958 (C/T)6.80 ± 0.0236.90 ± 0.0407.09 ± 0.1120.027
 rs2487999 (C/T)6.81 ± 0.0236.92 ± 0.0447.08 ± 0.200.21
African Americans (n = 574)
 rs4387287 (A/C)7.08 ± 0.0427.03 ± 0.0427.01 ± 0.0710.34
 rs9419958 (T/C)7.10 ± 0.0557.06 ± 0.0426.96 ± 0.0530.062
 rs2487999 (C/T)6.99 ± 0.0427.11 ± 0.0417.07 ± 0.0730.33
Both races (n = 1,893)
 rs4387287 (C/A)6.89 ± 0.0286.96 ± 0.0297.04 ± 0.0380.0026
 rs9419958 (C/T)6.89 ± 0.0256.99 ± 0.0297.06 ± 0.0490.0032
 rs2487999 (C/T)6.91 ± 0.0237.03 ± 0.0307.02 ± 0.0670.12
CXCR4 genotype*
 Whites of European descent (n = 1,593)
  rs4452212 (A/G)6.85 ± 0.0316.83 ± 0.0266.83 ± 0.0390.77
  rs4954585 (T/C)6.83 ± 0.0276.84 ± 0.0256.82 ± 0.0460.86
African Americans (n = 597)
 rs4452212 (G/A)7.06 ± 0.0367.02 ± 0.0496.84 ± 0.1150.098
 rs4954585 (C/T)7.04 ± 0.0467.09 ± 0.0396.95 ± 0.0650.26
  • Mean LTL (kb) according to genotype.

  • *Genotype 1 indicates zero copies, genotype 2 indicates one copy, and genotype 3 indicates two copies of the minor allele. The minor allele is listed second next to the rs number for each SNP. Note that the minor alleles may differ by race. P values reflect an additive genetic model.