Table 4.

Inhibition assays for enzymes and compound 1

EnzymeKi, nMFold loss*
Sa wild-type (WT)101.0
Sa (V31Y,F92I)18018
Sa (V31Y, F92S)878.7
Sa (V31F, F92L)13013
  • *Fold loss = Ki value for enzyme/Ki value for WT.