Table 2.

Transcripts encoding factors related to DNA replication and maintenance whose levels decrease significantly following treatment of T47D and MDA-MB-231 cells

SymbolGene nameFold change
RFC5Replication factor C (activator 1) 5, 36.5kDa0.72
NEIL3Nei endonuclease VIII-like 3 (E. coli)0.71
AURKBAurora kinase B0.71
GTSE1G-2 and S-phase expressed 10.64
RAD54LRAD54-like (S. cerevisiae)0.75
ARL3ADP ribosylation factor-like 30.81
BCCIPBRCA2 and CDKN1A interacting protein0.77
SKP2S-phase kinase-associated protein 2 (p45)0.65
RDM1RAD52 motif 10.75
PARP2Poly (ADP ribose) polymerase 20.86
RAD54BRAD54 homolog B (S. cerevisiae)0.67
ERCC6LExcision repair cross-complementing rodent repair deficiency, complementation group 6-like0.61
DCTPP1dCTP pyrophosphatase 10.78
DDB2Damage-specific DNA binding protein 2, 48kDa0.84
CDKN2CCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.64
AK3L1Adenylate kinase 3-like 10.84
APRTAdenine phosphoribosyltransferase0.84
DDB2Damage-specific DNA binding protein 2, 48kD0.84
BRCC3BRCA1/BRCA2-containing complex, subunit 30.83
TOP2ATopoisomerase (DNA) II alpha 170kD0.77
CDT1Chromatin licensing and DNA replication factor 10.74
RECQL4RecQ protein-like0.72
PARP1Poly (ADP ribose) polymerase 10.86
  • After Affymetrix microarray analyses, comparisons were done between two pools of cells treated with either unstimulated macrophage-conditioned medium or with LPS-stimulated macrophage-conditioned medium. The two pools contained four independent replicates from both T47D and MDA-MB-231 cell lines. Transcripts are arranged according to the decreasing values of P (all <1 × 10−7).