Table 1.

Summary of NV virus challenge studies in naïve chimpanzees

Peak seroconversion, EIA titer
Chimpanzee IDInoculum: genome copies (CID*)Day of onset of shedding, dpiDuration of shedding, daysPeak shedding titer, genome copies/g stoolWeek postinfectionPeakPeak virus titer in endoscope biopsies (genome copies/100 ng of RNA)Peak virus titer in liver biopsies (genome copies/100 ng of RNA)
16224 × 106 (0.1)3233 × 10761:1,600NCNC
16284 × 107 (1)4173 × 10721:800NCNC
A3A0234 × 107 (1)5226 × 10631:3,20022 (j/21 dpi)NC
A3A0084 × 108 (10)3426 × 10731:25,6001 × 106 (j/4 dpi)NC
A2A0144 × 107 (1)3318 × 10841:3,2003.5 × 104 (d/11 dpi)6 × 102 (l/7 dpi)
A3A0074 × 107 (1)2223 × 10941:6,4007 × 102 (d/ 9 dpi)1.3 × 102 (l/7 dpi)
  • NC, no sample was collected for that chimpanzee.

  • *CID, chimpanzee infectious dose. The original inoculum contained 10 CID.

  • In cases where more than one biopsy is NV positive, the highest genome copies/biopsy titer is reported, and the tissue of origin (j, jejunum; d, duodenum; l, liver)/date of collection (dpi) are reported in parentheses.