Table 1.

Viruses tested for their susceptibility to A3

VirusesGroupFamilyInhibition ofDegree of inhibition
Influenza A virus (A/WSN/33)(−) ssRNAOrthomyxoviridaeVirus∼5 logs (MOI = 0.01)
Influenza B virus (B/Yamagata/88)(−) ssRNAOrthomyxoviridaeVirus∼1.5 logs (MOI = 1)
Newcastle disease virus (La Sota)(−) ssRNAParamyxoviridaeVirus∼2 logs (MOI = 1)
Sendai virus (SV52)(−) ssRNAParamyxoviridaeVirus∼3 logs (MOI = 1)
Vesicular stomatitis virus(−) ssRNARhabdoviridaeVirus∼5 logs (MOI = 0.01)
Sindbis virus(+) ssRNATogaviridaeVirus∼2 logs (MOI = 1)
Hepatitis C virus*(+) ssRNAFlaviviridaeVirus∼2 logs (n.a)
West Nile virus(+) ssRNAFlaviviridaeReplicon cell line∼1 logs (NA)
Dengue I virus(+) ssRNAFlaviviridaeReplicon cell line∼1 logs (NA)
Vaccinia virus (NYVAC)dsDNAPoxviridaeVirus∼3 logs (MOI = 1)
Adenovirus (hAd5)dsDNAAdenoviridaeVirus∼6 logs (MOI = 5)
HIV-1,§ssRNA RTRetroviridaeVirus∼2 logs (NA)
  • NA, not applicable.

  • *Tested in Huh 7.5 cells.

  • Tested at 1 μM A3

  • Tested in TZM bl cells.

  • §Tested at 2 μM A3.