Table 1.

Electroretinogram a-wave analysis

Age (wk)CohortRmax (μV)σ (log scot cd−1m2s−3)nP
4Treated119.4 ± 11.43.66 ± 0.075120.583
Control105.8 ± 7.633.61 ± 0.04616
8Treated72.9 ± 4.973.62 ± 0.040180.003
Control59.4 ± 3.073.42 ± 0.04122
12Treated42.6 ± 3.453.60 ± 0.06120<0.0001
Control31.1 ± 1.623.25 ± 0.04424
16Treated28.5 ± 2.913.80 ± 0.07715<0.0001
Control17.5 ± 1.603.08 ± 0.10021
  • Rod response amplitudes (Rmax) and sensitivities (σ) from Bbs4−/− eyes injected at 2 wk of age. Treated eyes received scAAV5-mOP-BBS4, and control eyes received either scAAV5-mOP-GFP or no injection. P values were calculated using Hotelling's t-squared statistic.