Table 1.

Effect of MNR on fetal growth and cerebral development

ControlsMNR
Fetal growth
 Fetal body weight, g100.9 ± 3.895.4 ± 3.3
 Fetal brain weight, g32.6 ± 1.830.1 ± 0.5
 Ratio of the areas of the cortical plate/hemisphere0.17 ± 0.040.19 ± 0.03
Morphometric data
 Thickness, mm × 10−3
  SVZ0.75 ± 0.270.42 ± 0.09*
  Cortical plate0.81 ± 0.060.80 ± 0.09
 No. of proliferating cells per mm2
  SVZ13,830 ± 4,56819,711 ± 1,094*
  Cortical plate24 ± 1720 ± 18
  Intermediate zone3,612 ± 8413,773 ± 619
 Total no. of proliferating cells in the SVZ106,869 ± 5,393117,312 ± 1,094
 No. of apoptotic cells per mm2
  SVZ27 ± 960 ± 27*
  Cortical plate9 ± 412 ± 10
  Intermediate zone978 ± 3911,225 ± 473
 Ratio of programmed cell death/cell no.
  SVZ0.85 ± 0.211.86 ± 0.79
  Cortical plate7.94 ± 3.029.89 ± 3.20
  Intermediate zone0.58 ± 0.210.68 ± 0.60
  • *P < 0.05, P < 0.1 in comparison to controls.