Table 1.

TLR relative expression in stimulated human monocytes

Bb, 10:1 MOI
n = 6No inhibitorTLR8-inhibitedPam3CSSNA,10 μgR848,1 μg
TLR23.1 ± 0.51.9 ± 0.2*2.8 ± 1.72.2 ± 0.4
TLR85.8 ± 0.7−1.5 ± 0.6*−0.4 ± 1.914.2 ± 4.3
TLR71.4 ± 0.1−0.4 ± 1.2*−1.3 ± 0.23.6 ± 2.7
TLR9−3.6 ± 0.9−2.5 ± 0.7−1.5 ± 0.5−3.1 ± 1.3
  • Values represent relative changes in gene expression compared with GAPDH. MOI, multiplicity of infection.

  • *P < 0.05 (Mann–Whitney U test). Comparison analysis between TLR8-inhibited and -uninhibited Bb-stimulated monocytes.