Table 1

Mutation rates in exo1 mutants

StrainMutation rate
CanrHom+
Wild type
 RKY25758.4 × 10−87.7 × 10−9
 RKY25752.2 × 10−71.2 × 10−8
 RKY25371.3 × 10−7 (1)8.2 × 10−9 (1)
exo1
 RKY25878.1 × 10−74.0 × 10−8
 RKY25871.3 × 10−62.4 × 10−8
 RKY26631.2 × 10−6 (7.6) 1.1 × 10−7 (6.2)
msh2
 RKY25583.6 × 10−6 (25) 7.9 × 10−6 (850)
exo1, msh2
 RKY25883.9 × 10−6 (27) 7.2 × 10−6 (774)
  • The rate of accumulation of Canr mutants and Hom+ revertants per cell division is given. For wild-type and exo1 strains, data are shown from three experiments employing two isolates of the same genotype. For the msh2 and exo1, msh2 strains, data are from one experiment. The numbers in parentheses represent the fold induction relative to the wild-type value; for wild type and exo1, this number is the average of all three experiments.