Table 1

Mutations in epitope tagged MHM2 PrP inhibit PrPSc formation in ScN2a cells

Mo codon numberPrP residue*Mutant MHM2Type of inhibition of PrPSc formation
MouseHumanSyrian hamsterSheep
167QEQQ/RR2
E1
169SSNSNNone
170NN/SNNSNone
171QQQQR2
209VVVVK1
210EEEEKNone
211QQQQKNone
214VITII2
K1
E2
A1
W2
P1
215TTTTQNone
216QQQQR3
218QE/KQQE1
K2
I1
A2
W2
P1
F1
R2
H2
219KRKRRNone
221SSSSANone
222QQQQKNone
  • * Multiple residues at a particular position indicate naturally occurring polymorphisms. 

  • The corresponding codon number is that of Mo increased by one. 

  • The corresponding codon number is that of Mo increased by four.