Table 2

Mutations found in the CTNNB1 gene

Cell lineMutationMutation statusPredicted changeSite of mutationAPC status
SW48C → AHeterozygousSerine → tyrosineExon 3 (codon 33)Wild type
HCT 116Three-base deletionHeterozygousIn-frame deletionExon 3 (codon 45)Wild type
HCA 46G → THeterozygousAlanine → serineExon 5 (codon 183)Uncertain
Caco 2G → CHeterozygousGlycine → alanineExon 5 (codon 245)Mutant
Colo 201/205A → GHomozygousAsparagine → serineExon 6 (codon 287)Mutant