Table 1

Transforming activity of HPV16 E6 mutants

DesignationC end Binding to DLGTransformation of 3Y1 cellsTumorigenicity of ψ2 cells
16E6ETQL++9/10 (16-36)
16E6L151delETQ0/10§
16E6L151VETQV++7/10 (16-36)
16E6L151IETQI++NT
16E6L151PETQP0/10§
16E6L151LPETQLPNT
16E6L151ETQVETQETQV++NT
18E6ETQV++NT
11E6DLLP0/10
  • NT, not tested.

  • * Summarized data from Fig. 4.

  • Shown are the number of tumors (larger than 5 mm in diameter) per number of injected sites. Each mouse was injected at two sites. The minimal time (days, in parentheses) to produce apparent tumors of at least 5 mm in diameter.

  • No tumors were observed 36 days after injection.