Table 5

A two-allele selection model to describe the segregation observed in families for HLA-A and HLA-B

Parents Progeny
Female × MaleFrequencyA1A1A1A2A2A2
A1A1 × A1A1 P 11 2 1
A1A1 × A1A2 P 11 P 12 11
A1A1 × A2A2 P 11 P 22 1
A1A2 × A1A1 P 11 P 12 1 − s1
A1A2 × A1A2 P 12 2 1 − s11 − s
A1A2 × A2A2 P 12 P 22 11 − s
A2A2 × A1A1 P 11 P 22 1
A2A2 × A1A2 P 12 P 22 11
A2A2 × A2A2P2221
p1(p1 − ½ sP12)2p1p2p2(p2 − ½ sP12)
1 − ½ sP121 − ½ sP121 − ½ sP12