Incidence of selected tumors in HGF/SF transgenic mice

Mouse genotypeTotal miceMean age, monthsMammary tumorsAmelanotic melanomasRhabdo- myosarcomas
FemaleTG2715.2  ±  4.111  (41%)*1  (4%)0  (0%)
WT2913.0  ±  5.6 0  (0%)0  (0%)0  (0%)
MaleTG4215.3  ±  4.1 0  (0%)9  (21%)3  (7%)
WT2517.3  ±  3.8 0  (0%)0  (0%)0  (0%)
  • Tumor incidence is based on analysis of transgenic (TG) and wild-type (WT) mice >6 months of age. In TG mice <6 months of age, 3% had melanomas and 5% rhabdomyosarcomas. The presence or absence of tumors was based on gross inspection at necropsy. Tumors were classified by a variety of methods (see Materials and Methods). Liver tumor incidence also was significantly enhanced in aged TG mice; those data are presented elsewhere (39). Mean age is shown in months (±SD). 

  • Mammary tumors arose in both virgin and parous females, and include adenocarcinomas and adenosquamous carcinomas with hair follicle and mammary gland elements (see text). P < 0.0005. 

  • One of nine melanomas was metastatic to multiple organs. P < 0.05. 

  • One of these three rhabdomyosarcomas was metastatic to the pancreas.