Amounts of paclitaxel and metabolites excreted by intact mice within 96 hr after i.v. or oral administration of 10 mg/kg (body weight) of [3H]paclitaxel

Biological matrixCompoundi.v. administration Oral administration
Wild typemdr1a(−/−)Wild typemdr1a(−/−)
FecesPaclitaxel39.8 ± 2.61.5 ± 0.2*87.1 ± 8.82.2 ± 0.30*
3′-p-hydroxypaclitaxel8.6 ± 0.516.1 ± 0.82.4 ± 0.217.6 ± 1.9*
6α-hydroxypaclitaxel6.3 ± 0.413.8 ± 0.41.9 ± 0.511.3 ± 1.2*
3H label90.4 ± 5.534.3 ± 1.2*NANA
UrinePaclitaxel0.97 ± 0.100.78 ± 0.110.09 ± 0.030.07 ± 0.03
3′-p-hydroxypaclitaxel<0.01<0.01NDND
6α-hydroxypaclitaxel<0.01<0.01NDND
3H label15.9 ± 1.744.6 ± 4.7*NANA
  • Excretion is given as percentage of the dose (mean ± SEM; n = 4–6) NA, Not available; ND, not detectable. 

  • P < 0.05.