Amounts of paclitaxel and metabolites excreted by mice with cannulated gall bladder within 90 min after i.v. administration of [3H]paclitaxel

SampleCompoundDose, 10 mg/kg Dose, 5 mg/kg
Wild typemdr1a(−/−)Wild typemdr1a(−/−)
Plasma (level, ng/ml)Paclitaxel2020 ± 4202370 ± 280289 ± 38327 ± 44
BilePaclitaxel4.81 ± 0.272.56 ± 0.585.94 ± 1.704.10 ± 0.54
3′-p-hydroxypaclitaxel2.86 ± 0.282.48 ± 0.264.74 ± 0.694.10 ± 0.18
6α-hydroxypaclitaxel2.00 ± 0.251.29 ± 0.243.25 ± 0.511.98 ± 0.22
3H label17.9 ± 0.6915.0 ± 1.525.7 ± 4.526.6 ± 2.90
Intestinal contentsPaclitaxel10.77 ± 0.252.49 ± 0.86*3.53 ± 0.380.98 ± 0.28*
3-p-hydroxypaclitaxel
6α-hydroxypaclitaxel0.37 ± 0.100.37 ± 0.160.16 ± 0.05<0.1
3H label12.22 ± 0.283.79 ± 1.11*4.63 ± 0.491.52 ± 0.05
  • Excretion is given as percentage of the dose (mean ± SEM; n = 4). ND, Not detectable. 

  • P < 0.05. 

  • This compound could not be accurately quantified in the intestinal contents due to the presence of an interfering substance.