Table 3

Biliary and intestinal excretion of [3H]digoxin-derived radioactivity in mdr1a/1b (+/+) and mdr1a/1b (−/−) mice with a cannulated gallbladder

mdr1a/1b (+/+)mdr1a/1b (−/−)
Biliary excretion (% of dose)21.0 ± 3.413.6 ± 4.1*
Intestinal excretion (% of dose)16.1 ± 2.91.5 ± 0.3**
Plasma level (ng/ml) at 90 min21.2 ± 3.839.6 ± 5.1**
  • Female mice with a cannulated gallbladder and ligated common bile duct received an i.v. injection of [3H]digoxin (0.05 mg/kg). Bile was collected for 90 min. Intestinal contents and plasma levels were measured at the end of this period. Results are means ± SD (n = 4). *P < 0.05; **P < 0.002.